Searchable abstracts of presentations at key conferences in endocrinology

ea0094p158 | Adrenal and Cardiovascular | SFEBES2023

Development of PP-UHPLC-MS/MS workflow for the high-throughput and sensitive targeted steroid analysis of mouse plasma samples

Gazarkova Tatana , Plachka Katerina , Vlckova Hana Kocova , Svec Frantisek , Novakova Lucie

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids modulate the immune response to inflammation and affect whole-body metabolism. Despite numerous studies using traditional GC-MS...